While Germany and Spain are familiar foes in Wednesday's last-four clash, the Netherlands and Uruguay last played each other at the 1974 World Cup.
The Oranje won that game 2-0, and will be hoping for a repeat in 2010 on Tuesday.
Uruguay will be desperate to make it to their first final since 1950 - when they lifted the Jules Rimet Trophy - and will spend the next few days doing their homework.
"Oscar Tabarez has asked us to concentrate fully, not just in the matches, but also in training," said Sebastian Abreu, who scored the winning spot-kick in the South American's penalty-shootout win over Ghana with a cheeky chip down the middle.
"He is very satisfied with our work.
"Looking at Holland, we have watched a lot of videos on their team because we don't know too much about them.
"Holland and Uruguay play very similar football, but they have very good potential in their attack with very clever players like (Wesley) Sneijder and (Arjen) Robben.
"Tabarez has been talking to us about Robben and how to stop a player like him from going forward, but it's always different when you are on the field.
"So we know how to do it, but whether the actual execution actually comes off is another thing."