No way it's game over for Twente. Twente still have a very good squad, and the better coach of the top teams. If Ruiz stayed I couldn't imagine Twente not becoming champs this season. Now Ruiz leaves Twente obviously has become weaker, but remain strong. It does move Ajax to the number one favourite role, but I expect it to be close between the two. PSV could challenge also, but am not sure they will. I have very little faith in their coach to get the best out of the squad (not even close). Hopefully for the PSV fans Derijck will be a good influence to their defense, and Matavs probably is an awesome signing for them - expect a lot of goals from him.