It's going to be pretty balanced I think. Not many spaces since everyone will be marked and the only free players will be a CB for each team. I think the key player will be Biglia. If he manages to starve Dybala of service by blocking passing lanes to him, we'll be fine. The other key question will be Calabria against Mandzukic. I have a feeling Gattuso might play Zapata as a right back to make sure the can't use him as an easy outball. Calabria is really short and Mandzukic can destroy us physically on the left.
The rest is all evenly matched. Pjanic and Matuidi will challenge Kessie and Bonaventura, and there might me more spaces than usual for our guys on counters since they don't have a defensive shield like most teams in Serie A. We can get some good opportunities on counters if either of our midfielders manage to turn Pjanic/Matuidi since there will be lots of space behind them. Kessie is especially good at this, and Bonaventura does well also.
Juve obviously go into this with an advantage but I don't think it's impossible to go out with a draw or even a win if things go our way. They'll be distracted by Madrid and it doesn't seem like our guys are even thinking about the Derby.
Can't wait.